Bioequivalence Assessment of DM Tablet to Motilium-M® Tablet
Seong-Wan Cho, Young-Il Kim, Jong-Oh Lee, Joon Seok Bang and Ji Hoon J1eong
Department of Pharmaceutical Engineering, Konyang University, Nonsan, Chungnam, 320-711, Korea,Biomedieng, Seong-Nam, Keong-Ki, 462-901, Korea,College of Medicine, Chung-Ang University, Seoul, 156-756, Korea
This is an Open Access journal distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Abstract
- The aim of this study was to evaluate the bioequivalence of two domperidone preparations. Bioequivalence assessment was conducted on 34 healthy volunteers who received two tablets (Domperidone Maleate, 12.72 mg/tablet) in the fasting state, in a randomized balanced 2×2 cross-over study design. This whole study was performed according to theimplementation guidelines of the Korea Food Drug Administration. After dosing of two tablets, blood samples were collected serially for a period of 36 hours. Plasma was analyzed for domperidone by using LC/MS/MS assay method. The analysis system was validated in specificity, accuracy, precision, and linearity. AUCt, (the area under the plasmaconcentration-time curve from the zero-time to 36 hr) was calculated through the trapezoidal rule. Cmax (maximum plasma drug concentration) and Tmax (time to reach Cmax) were compiled from the plasma domperidone concentrationtime data of each volunteer. No significant sequence effect was found for the bioavailability parameters indicating that the cross-over design was properly performed. The 90%-Confidence intervals of the AUCt ratio and the Cmax were from log 0.8007 to log 1.1240 and log 0.8645- log 1.2483, respectively. These values were within the acceptable bioequivalence intervals between 0.80 and 1.25. Therefore, this study demonstrated that two formulations have bioequivalencewith respect to the rate and extent of absorption.
- Keywords : Domperidone, Bioequivalence, LC/MS/MS, Motilium-M®
- March 2025, 35 (1)
Full Text(PDF) Free- Social Network Service
-
- Services
- Cited By Articles
-
CrossRef (0)
