pISSN 1226-6051
eISSN 2508-786X

Table. 3.

Table. 3.

Predictive factors of sunitinib-induced hypothyroidism

Variables Unadjusted analysis Multivariable analysis


OR 95% CI p OR 95% CI p
Age ≥65 1.21 0.63-2.29 0.573 0.82 0.35-1.96 0.656
Female 2.94 1.27-6.79 0.007 2.77 1.03-7.50 0.044
Heng risk
Favorable 1.13 0.40-3.20 0.829 8.43 0.92-77.22 0.059
Intermediate 0.69 0.28-1.69 0.415 1.45 0.28-7.59 0.657
Poor 1.00 - - 1.00 - -
BMIa)
<25 1.15 0.19-7.14 0.879 0.20 0.02-2.38 0.202
25-29.9 1.31 0.19-9.02 0.782 0.16 0.01-2.16 0.168
≥30 1.00 - - 1.00 - -
Past nephrectomy 0.88 0.35-2.21 0.787 0.91 0.25-3.25 0.882
Sunitinib-induced HTN 4.05 1.87-8.77 0.008 2.99 1.10-8.15 0.032
Sunitinib-induced proteinuria 2.50 1.28-4.88 0.007 2.11 0.90-4.95 0.085
Sunitinib-induced renal injury 2.63 0.98-7.08 0.063 1.52 0.44-5.29 0.513
Number of cycles 1.12 1.04-1.21 0.008 0.91 0.82-1.01 0.064
Dose reduction due to other side effects 4.02 2.06-7.85 0.002 3.57 1.50-8.53 0.004

BMI: body mass index, CI: confidence interval, HTN: hypertension, OR: odds ratio

a)Evaluated in 148 patients

Korean J Clin Pharm 2024;34:184-93 https://doi.org/10.24304/kjcp.2024.34.3.184
© 2024 Korean J Clin Pharm