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Table. 5.

Table. 5.

Multivariate logistic analysis of patients with AEs

Pruritus

Crude ROR Adjusted ROR
Male 1.056 (0.854-1.307) 1.010 (0.815-1.251)
≥65 years 0.731 (0.589-0.907) 0.699 (0.563-0.869)
DPP-IV inhibitor 2.474 (1.968-3.111) 2.534 (2.014-3.189)

Rash

Crude ROR Adjusted ROR

Male 2.024 (1.508-2.715) 1.920 (1.429-2.579)
≥65 years 0.596 (0.439-0.810) 0.592 (0.435-0.805)
DPP-IV inhibitor 2.591 (1.899-3.535) 2.622 (1.919-3.583)

Urticaria

Crude ROR Adjusted ROR

Male 1.055 (0.748-1.488) 0.981 (0.694-1.385)
≥65 years 0.391 (0.265-0.578) 0.377 (0.254-0.557)
DPP-IV inhibitor 2.058 (1.409-3.006) 2.188 (1.496-3.201)

Bullous eruption/Papulovesicular rash

Crude ROR Adjusted ROR

Male 7.228 (1.583-33.002) 6.928 (1.513-31.716)
≥65 years 0.83 9(0.266-2.645) 0.876 (0.277-2.773)
DPP-IV inhibitor 3.716 (1.178-11.723) 3.534 (1.117-11.180)

Arthralgia

Crude ROR Adjusted ROR
Male 1.237 (0.415-3.683) 1.091 (0.365-3.263)
≥65 years 0.352 (0.097-1.280) 0.319 (0.087-1.166)
DPP-IV inhibitor 6.078 (2.040-18.107) 6.473 (2.166-19.347)

Pharyngitis

Crude ROR Adjusted ROR
Male 2.499 (1.188-5.256) 2.145 (1.013-4.545)
≥ 65 years 0.586 (0.274-1.254) 0.504 (0.234-1.086)
DPP-IV inhibitor 73.880 (17.585-310.384) 75.098 (17.855-315.867)

Coughing

Crude ROR Adjusted ROR

Male 1.154(0.455-2.927) 1.177 (0.463-2.995)
≥65 years 3.059(1.090-8.587) 2.847 (1.010-8.024)
DPP-IV inhibitor 5.241(2.067-13.154) 4.875 (1.928-12.326)

AE, adverse event; DPP-IV, dipeptidyl peptidase-IV; ROR, reporting odds ratio

Adjusted RORs were calculated using logistic regression by adjusting for sex and age.

Korean J Clin Pharm 2024;34:100-7 https://doi.org/10.24304/kjcp.2024.34.2.100
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