pISSN 1226-6051
eISSN 2508-786X
eISSN 2508-786X
Detected signal of DPP-IV inhibitors according to SOC levels
| SOC levels | Reports of AE (n) | Crude ROR (95% CI) | ||
|---|---|---|---|---|
| AE | Code | DPP-IV inhibitor | Other oral hypoglycemic agents | |
| Gastrointestinal system disorders | 0600 | 400 | 3,172 | 0.546 (0.484-0.616) |
| Metabolic and nutritional disorders | 0800 | 466 | 1,882 | 1.396 (1.240-1.571) |
| Central & peripheral nervous system disorders | 0410 | 191 | 892 | 1.126 (0.954-1.329) |
| Skin and appendages disorders | 0100 | 248 | 684 | 2.036 (1.742-2.379) |
| Body as a whole, general disorders | 1810 | 120 | 621 | 1.003 (0.819-1.229) |
| Urinary system disorders | 1300 | 41 | 414 | 0.502 (0.363-0.695) |
| Psychiatric disorders | 0500 | 58 | 379 | 0.787 (0.594-1.043) |
| Musculo-skeletal system disorders | 0200 | 43 | 144 | 1.565 (1.108-2.209) |
| Liver and biliary system disorders | 0700 | 17 | 110 | 0.800 (0.479-1.337) |
| Cardiovascular disorders |
1010,1020, 1030,1040 | 20 | 104 | 0.998 (0.617-1.616) |
| Respiratory system disorders | 1100 | 55 | 68 | 4.308 (3.008-6.171) |
| Blood disorders |
1210,1220, 1230 | 3 | 47 | 0.330 (0.103-1.062) |
| vision disorders | 0431 | 4 | 35 | 0.592 (0.210-1.669) |
| Special senses other, disorders | 0433 | 1 | 30 | 0.173 (0.024-1.266) |
AE, adverse event; DPP-IV, dipeptidyl peptidase-IV, ROR, reporting odds ratio; SOC, system organ class
aCardiovascular disorders included heart rate and rhythm disorders, general cardiovascular disorders, myo,endo,pericardial & valve disorders, vascular disorders
bBlood disorders included platelet, bleeding & clotting disorders, red blood cell disorders, white cell and RES disorders