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Table. 1.

Table. 1.

Characteristics of studies

Study name(Year) Country of study Study design No. of Linezolid Study duration No. of patients LZD dosage Duration of LZD treatment
Jesu's FortĂșn et al. 16) (2005) Spain Retrospective case series 5 1994-2004 0 600mg bid Range=4-24 months / Mean=12 months / Median=12 months
Bent Von der Lippe et al. 33) (2006) Norway Retrospective case series 10 1998-2002 1 600mg bid Range=2-10 months / Median=4.25 months
I-Nae Park et al. 17) (2006) South Korea Prospective non-randomized case series 8 2003-2006 5 600mg daily / 600mg bid Range=3-18 months / Median=9 months / Mean=11 months
Rany Condos et al. 15) (2008) USA Prospective phase 1 clinical trial 7 2000-2007 7 600mg bid / 600mg daily Range=9-26 months
G. B. Migliori et al. 31) (2009) Belarus, Germany, Italy, Switzerland Retrospective nonrandomized unblinded observational study 85 2001-2007 10 600mg daily / 600mg bid Mean=7 months / Median=3 months
Hae-Seong Nam et al. 32) (2009) South Korea Retrospective case series 11 NR 4 600mg daily / 300mg bid Range=3-24 months / Mean=7 months / Median=5 months
Won-Jung Koh et al. 41] )(2009) South Korea Retrospective case study 24 2007-2008 24 300mg daily Median=289 days, IQR=233-405 days / Median=104 days, IQR=26-145 days
G. F. Schecter et al. 20) (2010) USA Retrospective case series 30 2003-2007 3 600mg daily Range=1-36 months / Mean=19 months / Median=22 months
Holly A. Anger et al. 14) (2010) USA Retrospective case series 16 2000-2006 10 600mg bid / 400mg bid / 600mg daily Mean=15 / Median=16 / Range=1-29 months
Z, F, Udwadia et al. 42) (2010) India Prospective case study 78 2004-2007 18 600mg daily Median=20.6 months
M. Villar et al. 38) (2011) Portugal Prospective case series 16 2004-2009 12 600mg daily / 1200mg daily Median=375 days
Shen-Jie Tang et al. 39) (2011) China Prospective case series 14 2009-2010 14 600mg bid / 600mg daily Range=2-11 months / Mean=6.5 months
Eduardo Abbate et al. 28) (2012) Argentina Retrospective study 17 2002-2008 17 600mg bid >12 months after cc
Chang-Min Lee 18) (2012) South Korea Retrospective study 24 2011-2012 9 600mg daily / 300mg daily Range=101-524 days
S. De Lorenzo et al. 23) (2012) Italy Retrospective study 12 2009-2010 4 600mg bid / 600mg daily / 450mg bid Range=37-100 months / Median=63.5 days
H-B. Xu et al. 27) (2012) China Retrospective case series 18 2007-2010 15 600mg bid / 900mg daily Range=1.5-10 months / Median=6 months
Myung sun Lee et al. 36) (2012) South Korea Phase 2a randomized two-group study 39 2008-2011 39 600mg daily 22 months
R. Singla et al. 37) (2012) India Prospective case series 29 2006-2011 16 600mg bid / 600mg daily Median=30 days
Won-Jung Koh et al. 30) (2012) South Korea Retrospective case series 51 2007-2009 26 300mg daily Median=413 days / IQR=237-622 days
Alena Tse-Chang et al. 40) (2013) Canada Retrospective case study 13 2000-2011 NR 600mg daily Range=1.4-22 months / Mean=8.3 months
Chaiyos Roongruangptayakul et al. 19) (2013) Thailand Retrospective case series 24 2009-2012 7 600mg daily / 300mg daily Range=11-21.5 months / Mean=18.7 months
L. Zhang et al. 34) (2014) China Retrospective 15 2012-2013 15 600mg daily Range=1-5 months
Shen-jie Tang et al. 35) (2014) China Prospective multicenter randomized controlled study 33 2009-2011 33 1200mg daily / 300-600mg daily Range=2-24 months
Yu Liu et al. 21) (2015) China Retrospective case series 16 2011-2013 16 600mg daily Range=3-21 months / Mean=9.53 months
Lina Yi et al. 29) (2016) Japan Retrospective study 26 2009-2015 7 1200mg daily / 600mg daily Range=210-330 days
Farouq Muhammed Dayyab et al. 24) (2021) Nigeria Prospective cohort study 39 2018-2019 0 600mg daily 10 months

XDR-TB: Extensively resistance tuberculosis, LZD: Linezolid, bid: Two times a day, cc: Chief complaint, IQR: Inter Quatile Range, No. of Linezolid: Number of patients exposed to Linezolid, No. of patients: Number of XDR-TB patients

Korean J Clin Pharm 2023;33:278-89 https://doi.org/10.24304/kjcp.2023.33.4.278
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