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Table. 2.

Table. 2.

Overview of Literature

Author (Year) Country Participant (I/ C) Participant characteristi cs Intervention/treatment Methods Outcome measure (Primary/Secondary)


Number Randomized Age (Mean±SD) Female (%) Intervention Control
Vedaa Ø 2020 22) Norway 868
853
44.2±13.9
44.8±13.7
69
67
Adults (age≥18 years) dCBT[SHUTi] Patient education • Online, fully automated, interactive, and tailored web-based program that incorporates the primary tenets of face-to-face CBT-I, including sleep restriction, stimulus control, cognitive restructuring, sleep hygiene, and relapse prevention.
• Offered in a 6-week
• ISI,BIS, Sleep diary
• CFQ,HADS, QoL, SF-12
Kallestad H 202123) Norway 49
52
41.54±10.5
41.3±12
71
79
Adults dCBT[SHUTi] Face to face CBT-I • Use the internet CBT-i (SHUTi) intervention site, then use the program for six weeks.
• No Therapist
• ISI, DBAS-16 item, SOL, WASO, EMA, TST, NOW, SE, Sleep Med
• CFS, HADS
Morris J 201624) UK 36
32
44
20.69±2.61
20.56±1.54
20.27 1.56
60.4
72.1
70.2
Students with insomnia Insomnia Relief Wait-list group • Online Cognitive behavioral treatment for insomnia offered in a 6-week
• programs are ungui
• ded internet-delivered self-help programs featuring CBT components broken into 7 and 6 modules
• PSQI
• STAI-S, BDI-II
Lancee J 201225) Netherlands 216
205
202
52.2±11.4
51.2±12.8
51.9±2.2
68.7
74.4
68
Adults with insomnia (age≥19 years) Electronic self-help CBT 1.Paper-and-pencil self help CBT
2.wait-list group
• Online Cognitive behavioral treatment for insomnia (5 modules)
• fill out questionnaires and a dairy at baseline post-test, 3-month follow-up, and 6-month follow-up.
• Sleep diary(SE, TST, SOL, WASO, NWAK, SLEEP-50
• CES-D, HADS
Thiart H 201526) Germany 64
64
48.4
47.6
20.4
18.9
school teacher and working; Adults with insomnia (age≥18 years) GET.ON Recovery Wait-list group • GET.ON Recovery comprises six -week.
• The intervention modules(5 modules) include planning of recreational activities into daily life, monitoring sleep efficiency and continuing with sleep hygiene and restriction.
• ISI, SE, Recuperation in sleep
• Irritation scale, Penn State Worrying Questionnaire, REQ
Vincent N 200927) Canada 59
59
NA 67.8
66.1
Adult with insomnia Online Treatment Wait-list group The online treatment was developed by the first author and organized into 5 modules.
• Treatment component delivery offered in a 6-week in-person group at the same site.
TST, SOL, NOW, WASO, SE, SQ, MFI, ISI
Black DS 201528) USA 24
25
66.5±6.3
66.1±8.5
67
68
Adult (age of at least 55 years) • MAPs mindful awareness practices Sleep hygiene education (SHE) MAPs for daily living is a weekly 2-hour, 6-session group-based course
• Mindfulness practice homework began with 5 minutes daily and then progressively advanced to 20 minutes daily by session 6.
• PSQI, AIS
• BDI-II , BAI, PSS, FSI–Interference, FSI–Severity
Zhang JX 201529) China 30
30
78.57±2.94
77.63±3.01
46.7
36.7
Participants included 60 adults aged 75 years and over with chronic insomnia. MBSR Wait-list group • MBSR was conducted using a mild modified format for eight weeks, with two-hour classes and a 0.5-day retreat • PSQI
• SAS, GDS
Lorenz N 201930) Switzerland, Australia, Germany 29
27
41.72±17.31
44.04±20.05
72
67
Adults with insomnia (age≥18 years) internet-based CBT-I (mementor somnium) Wait-list group • The intervention was 6 weeks.
• web-based unguided self-help programme with automated feedback
• ISI, SRBQ
• APSQ, BDI-II, BSI-Anxiety, BSI-Somatization, Somatization subscale of the Brief Symptom Inventory
Siebmanns S 202131) Sweden 24
24
72.46±9.45
72.58±10.37
29.2
41.7
Adults with insomnia (age≥18 years) I-CBTI Patient education • 9-week nurse-led I-CBTI with support • ISI
• SF-12,PCS, MCS
Vestergaard CL 202132) Norway 867
853
44.2±13.9
44.8±13.7
69
67
Adults with insomnia dCBT[SHUTi] Patient education • SHUTi program consists of 6 cores
• fully automated and follow-up assessments were administered 9 weeks after the participant started with the intervention
• ISI, Consensus Sleep Diary(SOL, WASO, TST etc)
• HADS
EM Abdelaziz 202133) Saudi Arabia 40
40
53.90±4.14
52.23±4.31
100
100
Postmenopausal women with insomnia internet-based CBT-I Wait-list group • 6 modules at a fixed time per week delivered via whats APP or email
• Upon module execution, notifications are sent to participants to provide feedback on compliance with previous recommendations.
• There is a certain amount of time for discussion between researchers and participants, such as text messages, phone calls, and e-mails.
• ISI, PSQI, sleep diary(SE, TST, Wake up time, night awakening, SL)
D Behrendt 202034) Germany 88
89
46.1±9.5
46.7±9.7
67
64
General Working Population (18+) Internet-Based Sleep Recovery Training (iCBT) Wait-list group • Online-based CBT-I tailored for workers
• Intervention consists of a total of 6 modules, one per week
• One module is 45-60 minutes long
• Technical support via email only
• Provide materials on a secure web-based platform
• ISI
• CES-D, Recreational activity frequency, work ability, depression, absenteeism, CA
R Sunnhed 202035) USA 72
73
74
51.5±12.5
51.8±14.5
54.2±14.6
76.4
69.9
73
Adults with insomnia Internet-Based CBTI 1.Wait-list group
2.Behavioral therapy(BL)
• 10-week course with one module per week over the Internet
• Provide a phone call in case of missing
• ISI, sleep diary(SOL, WASO, EMA, TST, TIB, SE)
• WSAS, HADS, BBQ, CEQ, CSQ-8
Cain MA 202036) USA 27
26
28.5±5.8
29.8±5.3
100
100
Pregnant women with insomnia “Go! to Sleep©” GTS Sleep hygiene education (SHE) • 6-week web-based program
• “Go! to Sleep©”(GTS)
• PSQI, ISI
Kalmbach DA 202037) USA 46
45
28.91±28.91
29.16±4.11
46
45
Pregnant women with insomnia dCBTI(Sleepio) Sleep hygiene education (SHE) • sleepio program (big health ltd)
• Consists of 6 sessions
• Delivered by email 1 per week for 6 weeks
• ISI, PSQI
• EPDS, PSAS-C
Espie CA 201238) UK 55
55
54
50.7±13.8
47.3±13.0
72.7
76.4
70.4
Adults with insomnia (age≥18 years) Online CBT virtual therapist (The Prof) Online IRT (image palliative therapy)
TAU
• Animated ‘the prof’ offers 6 weekly sessions
• Personalized provision based on sleep diary data
• Sleep diary (SE, SOL, WASO,TWT, TST), SQ, Sleep condition indicator
Glozier N 201939) Australia 45
42
58.6±6.3
58.1±6.1
0 Male over 50 years of age with symptoms of depressive disorder and insomnia eCBTi SHUTi Online Insomnia Psychological Training • SHUTi.
• Consists of 6 modules, each taking 30-40 minutes
• Provides personalized recommendations
• ISI
• CES-D, HAM-D, STPI
Bernstein AM 201740) USA 43
45
54.9±13.0
53.6±12.3
88.4
88
adults with primary insomnia “Go! to Sleep©” GTS Sleep hygiene education (SHE) • The six-week web-based program “Go! to Sleep©” (GTS) • ISI
Nilofar Rajabi Majd 202041) Iran 156
156
36.21±5.81
35.29±5.76
53.9
57.7
Adults with insomnia (age≥18 years) theory-based app (including cognitive behavioral therapy [CBT], theory of planned behavior [TPB], health action process approach [HAPA], and control theory [CT]) Sleep hygiene education (SHE) • App that combines TPB, HAPA, and CBT-I
• Content every week for 6 weeks
• One session must end before the next one opens.
• Provided in the form of text and video, with homework or exercise
• No personalized content
• ISI, PSQI, SHB
• PBC, SRBAI, HADS
J Sveen 202142) Sweden 10
11
49.9±5.8
45.6±5.5
70
64
Parents of children diagnosed with a malignant tumor before age 17 and died of a malignancy before age 25 with insomnia Internet-Based Cognitive Behavioral Therapy (iCBT-i) Active control (written information about sleep, insomnia and sleep hygiene) • Active therapist intervention for 9 weeks (feedback provided when going to the next module)
• One module per week, sleep diary included
• ISI
• PG-13, MADRS, GAD-7, PCL-5, UGRS, CSQ-8
Espie CA 201943) UK 853
858
48.4±13.9
47.7±13.6
76.7
78.7
Adults with insomnia dCBT(Digital Insomnia Therapy to Assist Your Life as Well As Sleep [DIALS]) Sleep hygiene education (SHE) • Delivery using sleepio program (big health ltd) and related ios apps
• Consists of 6 sessions lasting 20 minutes and accessible for up to 12 weeks
• ESS, SCI
• PROMIS-10, WEMWBS, GSII, PHQ-9, GAD-7, FSS, RAS, CFQ, WPAI:SHP
Faaland P 202244) Norway 345 47.7±12.21 NA Adults with insomnia (age≥18 years)
Morning chronotype
SHUTi Morning Patient Education Morning • Fully automated online interactive 9-week web-based program
• secondary analysis of data from a previously published RCT
• Participants are classified into three types of chronotype through the Insomnia Questionnaire.
• ISI
• CFQ, HADS
843 46.6±14.46 NA Adults with insomnia (age≥18 years)
Intermediate chronotype
SHUTi Intermediate Patient Education Intermediate
524 39.3±13.21 NA Adults with insomnia (age≥18 years)
Evening chronotype
SHUTi Evening Patient Education Evening
Cheng P 202045) USA 358
300
44.5±15.8
45.7±15.1
78
80
Adults with insomnia and depression dCBT-I Sleepio Online sleep education • Participants were provided each of the 6 core sessions of dCBT-I on a weekly basis for up to 12 weeks.
• directed by an animated “virtual therapist” who reviews and guides progress
• ISI
• QIDS-SR16, PTQ
Chow PI 201846) USA 302
303
43.3±11.6 72 Adults with insomnia
(21 to 65 years)
dCBT[SHUTi] Online Patient education • Fully automated online interactive 9-week web-based program • ISI, SOL, WASO, Insomnia Knowledge,SLOCS, SSE,
• DBAS
de Bruin EJ 201547) Netherlands 18
14
15.4±1.4
16.6±1.7
77.8
85.7
Adolescents (13–19 years) with insomnia online CBTI Wait-list group • six weekly preprogrammed consults of CBTI via an internet website
• Each week short personalized feedback from a certified sleep therapist was included
• After the second session, a 15-minute chat session with a therapist is included to promote treatment compliance and outcomes.
• TST, TIB, SOL, WASO, SE, FI, SSQ
• CSRQ, HSDQi
van der Zweerde T 201948) Netherlands 52
52
44.64±1.82
46.29±2.09
80.8
82.7
Adults with insomnia online CBT-I and sleep diary monitoring i-Sleep Sleep diary monitoring only • Online intervention i-Sleep consists of five sessions of CBT for insomnia
• Clinical psychology graduate students offered online guidance entailed feedback
• ISI, FSS, SE, TST, WASO, SOL
• HADS, DC, PTQ, Mood, PHQ-WS, PHQ-9
Ritterband LM 201749) USA 151
152
43.75±11.34
42.81±11.86
68.2
75.7
Adults with insomnia dCBT[SHUTi] Patient education • Fully automated online interactive 6-week web-based program • ISI, SOL, WASO, SE, NWAK, SQ, TST
Sato D 202250) Japan 79
88
103
49.8±11.1
50.5±11.0
51.0±10.4
40.5
44.3
39.8
Adults with insomnia (20 to 70 years) ICBT Three GoodThings (TGT) wait-list group • Underwent an unguided ICBT program for 4 weeks • AIS,PSQI, SOL, TST, SE
• GAD-7, PHQ-9, CES-D
Ritterband LM 200951) USA 22
22
44.68±10.61
45.05±11.67
81.82
72.73
Adults with insomnia (18 to 65 years) dCBT[SHUTi] wait-list group • Fully automated online interactive 9-week web-based program • WASO, SOL, SE, TST, NWAK, TIB
• Restored, Restless
Minde ll JA 201152) USA 96
84
NA 100 264 mothers and their infant or toddler (ages 6-36 months) Algorithmic internet-based intervention alone Wait-list group • 3-week Internet-based sleep program
• All mothers completed the Brief Infant Sleep Questionnaire, the Pittsburgh Sleep Quality Index, and the Profile of Mood States weekly.
• BISQ, Maternal Sleep(PSQI): Bedtime, SOL, Waketime, TST, Night Wakings, Time Awake Night, SE, GSQ
• POMS
de Bruin EJ 201553) Netherlands 39
39
38
15.3±1.4
15.9±1.6
15.6±1.7
84.6
71.8
68.4
Adolescents (12–19 years) with insomnia internet therapy Wait-list group
group therapy
• six weekly preprogrammed consults of CBTI via an internet website
• Each week short personalized feedback from a certified sleep therapist was includedAfter the second session, a 15-minute chat session with a therapist is included to promote treatment compliance and outcomes.
• SE, SOL, WASO, TST, TIB, SQ, HSDQ, CSRQ
Kaldo V 201554) Sweden 73
75
47±15.2
49±15.6
81
76
Adults with insomnia ICBT-i Active control treatment Patient education • 8 weeks of ICBT-i treatment.
• Therapists review homework reports and sleep diaries and provide feedback
• ISI, SE, SL, sleep time
• PSS-4
van Straten A 201455) Netherlands 59
59
48.7±13.8
50.1±11.9
59.30
81.40
Adults with insomnia guided Internet Wait-list group • 6-week internet-based program.
• The first author, four master psychology courses, and one CBT therapist became coaches to provide online feedback on the participants' homework
SQ, PSQI(SE, SOL, TST)
• HADS, CES-D
Lancee J 201656) Netherlands 30
30
30
41.2±14.1
38.5±13.1
45.1±13.7
86.7
73.3
83.3
Adults with insomnia online CBT-I Face-to-face CBTi
Wait-list group
• Online therapy consists of 5 modules over 6 weeks (1) psychoeducation; (2) progressive muscle relaxation; (3) sleep hygiene; (4) sleep restriction (5) cognitive exercises
• Under the supervision of the first author, students with master's degree in psychology provided personal feedback.
• ISI, TST, SE, TWT
• CES-D, HADS-A
Ritterband LM 201257) USA 14
14
53.7±10.8
59.6±12.3
14
10
Cancer patients with insomnia dCBT[SHUTi] wait-list group • Fully automated online interactive 9-week web-based program • ISI, Sleep diary
• MFSI-SF, HADS, SF-12, IIUQ
Taylor DJ 201758) USA 34
33
33
34.53±8.27
30.79±6.42
32.82±8.11
18
21
12
Active duty US Army personnel Internet CBTi In-person CBTi
Minimal Contact Control
• the form of an automated online format
• 6-weekly 60min intervention consisted of stimulus control, sleep restriction, sleep hygiene, relaxation training, and cognitive restructuring.
• ISI, DBAS, ESS
• DSM-5, BDI-II, PTSD Military Ver, AUDIT
Ström L 200459) Sweden 30
51
46.2±11.6
43.9±11.4
66.67
62.75
Adults with insomnia Internet-based treatment Wait-list group • 5-week intervention mainly consisted of sleep restriction, stimulus control, and cognitive restructuring.
• Two clinical psychologists served as therapists for e-mail interaction and monitoring of homework assignments
• SE, SQ, TST, SOL, DBAS, Sleep diary(WASO, TIB, TWT, NWAK, No. of nights with sleep aid)

Note. ISI=Insomnia Severity Index; BIS=Bergen Insomnia Scale; CFQ=Chalder Fatigue Questionnaire; HADS=Hospital Anxiety and Depression Scale; QoL = Quality of Life; SF-12=12-Item Short Form Survey; DBAS=Dysfunctional Beliefs About Sleep Scale; SOL=Sleep Onset Latency; WASO =Wake Time After Sleep Onset; EMA=Early Morning Awakening; TST=Total Sleep Time; NOW=number of nocturnal awakenings; SE=Sleep Efficiency; Sleep Med=number of nights with sleep medication; CFS=Chronic fatigue syndrome; PSQI=Pittsburgh Sleep Quality Index; STAI-S=State-Trait Anxiety Inventory-State; BDI-II=The Beck Depression Inventory – Second Edition; NWAK =Number of awakenings; CES-D=Center for Epidemiologic Studies Depression Scale; REQ=Recovery Experience Questionnaire; SQ=Sleep Quality; MFI=Multi-Dimensional Fatigue Inventory; AIS=Athens Insomnia Scale; BAI=Beck Anxiety Inventory; PSS=Perceived Stress Scale; FSI=Fatigue Symptom Inventory ; MBSR: Mindfulness-based stress reduction; SAS =Self-rating Anxiety Sale; GDS=Geriatric Depression Scale; SRBQ =Sleep-related Behaviours Questionnaire; APSQ =Anxiety and Preoccupation about Sleep Questionnaire; BSI=Brief Symptom Inventory ; PCS =a physical component score; MCS=a mental component score; SL=Sleep Latency; CSD=Consensus Sleep Diary; WA =work ability; CA=cognitive activity; TIB=Time In Bed; BBQ=Brunnsviken Brief Quality of Life; CEQ=Creative Experience Questionnaire; CSQ-8=Client Satisfaction Questionnaire; EPDS=Edinburgh Postnatal Depression Scale; PSAS-C=Presleep Arousal Scale – Cognitive subscale; TWT =Total wake time; HAM-D=Hamilton Depression Rating Scale; STPI = State-Trait Personality Inventory; SHB=Sleep hygiene behavior; PBC=perceived behavioral control; SRBAI=Self-Report Behavioral Automaticity Index; PG-13 =The Prolonged Grief Disorder-13; MADRS=Montgomery-Asberg Depression Rating Scale; GAD-7=Generalized Anxiety Disorder-7; PCL-5=Posttraumatic stress; UGRS=The Utrecht Grief Rumination Scale; ESS=Epworth Sleepiness Scale ;SCI=Sleep Condition Indicator; PROMIS-10=Patient-Reported Outcomes Measurement Information System 10-Question; WEMWBS=Warwick-Edinburgh Mental Wellbeing Scale; GSII=Glasgow Sleep Impact Index; PHQ-9=Patient Health Questionnaire- 9; FSS=Fatigue Severity Score; RAS=Reticular Activating System; WPAI:SHP=Work Productivity and Activity Impairment Specific Health Problem Questionnaire; QIDS-SR16=Quick Inventory of Depressive Symptomatology; PTQ=Perseverative Thinking Questionnaire; SLOCS=Sleep Locus of Control Scale; SSE=Sleep Self-Efficacy; FI=fragmentation index; SSQ=Split Sleep Questionnaire; CSRQ=Chronic Sleep Reduction Questionnaire; HSDQi =Holland Sleep Disorder Questionnaire-Insomnia symptoms; DC=Daytime Consequences; PHQ-WS=Patient Health Questionnaire-9 without sleep item; BISQ=Brief Infant Sleep Questionnaire; GSQ=Global Sleep Quality; POMS=Profile of Mood States; HSDQ=Holland Sleep Disorders Questionnaire; PSS-4=Perceived Stress Scale 4; HADS-A=Hospital Anxiety and Depression Scale-Anxiety subscale; MFSI-SF=Multidimensional Fatigue Symptom Inventory - Short Form; IIUQ =Internet Intervention Utility Questionnaire; DSM-5=Diagnostic and Statistical Manual of Mental Disorders Fifth Edition; PTSD=Post Traumatic Stress Disorder; AUDIT=Alcohol Use Disorders Identification Test

Korean J Clin Pharm 2023;33:221-41 https://doi.org/10.24304/kjcp.2023.33.4.221
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