pISSN 1226-6051
eISSN 2508-786X
eISSN 2508-786X
Definition and signal detection criteria of data-mining indices
| Indices | Definition | Criteria for signal detection |
|---|---|---|
| PRR (Proportional Reporting Ratio) | {A/(A+B)}/{C/(C+D)} | PRR ≥2, Chi-squared ≥4, A ≥3 |
| ROR (Reporting Odds Ratio) | (A/B)/(C/D) | ROR ≥2, Chi-squared ≥4, A ≥3 |
| IC (Information Component) | Log2P(AE, drug) / P(AE)P(drug) | Under limit of 95% confidence interval ≥0 |
| Specific adverse event | All other adverse event | |
| Specific drug | A | B |
| All other drugs | C | D |