pISSN 1226-6051
eISSN 2508-786X
eISSN 2508-786X
Definition and signal detection criteria of data mining indices
Number of reports | Specific Adverse Event | All other Adverse Events | Total |
---|---|---|---|
Drug of interest | A | B | A+B=E |
Another drug | C | D | C+D=F |
Total | A+C=G | B+D=H | A+B+C+D=I |
Indices | Definition | Criteria for signal detection | |
Disproportionality ratio | PRR | (A/E)/(C/F) | ROR ≥ 2, x^{2} ≥ 4, A ≥ 3 |
ROR | (A/B)/(C/D) | PRR ≥ 2, x^{2} ≥ 4, A ≥ 3 | |
IC | log2(A+0.5)/ ((E*G/I)+0.5)) | IC under limit of 95% confidence interval ≥ 0 |
IC, information component; PRR, proportional reporting ratio; ROR, reporting odds ratio