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Table. 3.

Table. 3.

GRADE evidence profile

Outcome No. of studies (No. of participants) Certainty assessement Summary of findings

Risk of bias Inconsistency Indirectness Imprecision Other considerations Absolute (95% CI) Certainty
BMI 6 RCTs (238 participants) Not serious Not serious Serious Not serious None MD 0.73 lower (1.95 lower to 0.50 higher) ⨁⨁⨁◯ Moderate
LBM 6 RCTs (204 participants) Not serious Not serious Not serious Not serious None MD 1.86 higher (1.43 higher to 2.30 higher) ⨁⨁⨁⨁ High
Body fat 7 RCTs (223 participants) Not serious Very serious Not serious Not serious None MD 6.32 lower (10.58 lower to 2.06 lower) ⨁⨁◯◯ Low
Weight 3 RCTs (93 participants) Not serious Not serious Serious Not serious None MD 0.31 higher (0.73 lower to 1.36 higher) ⨁⨁⨁◯ Moderate
IGF-1 3 RCTs (100 participants) Not serious Not serious Not serious Not serious None MD 241.62 higher (68.59 higher to 414.64 higher) ⨁⨁⨁⨁ High
Fasting insulin 4 RCTs (184 participants) Not serious Serious Serious Not serious None MD 2.87 higher (0.88 lower to 6.62 higher) ⨁⨁◯◯ Low

BMI: body mass index, CI: confidence interval, IGF-1: Insulin-like growth factor 1, LBM: lean body mass, MD: mean difference, RCT: randomized controlled trial

Korean J Clin Pharm 2022;32:336-51 https://doi.org/10.24304/kjcp.2022.32.4.336
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