pISSN 1226-6051
eISSN 2508-786X

Table. 2.

Table. 2.

Results of the multiple logistic regression analysis of factors affecting the prescription of contraindicated drug combinations

Explanatory variables Contraindicated drugs in combinations causing serotonin syndrome

Adj. OR 95% CI P-value
Sex Male (R)
Female 0.737 0.537-1.015 0.060
Age (years) 20-39 (R)
40-49 0.691 0.300-1.563 0.374
50-64 1.791 0.928-3.648 0.093
65-74 2.120 1.096-4.343 0.031
≥75 1.313 0.671-2.716 0.442
Insurance NHI (R)
Non-NHI 0.716 0.400 -1.191 0.227
Comorbidities Hypertension 0.915 0.642-1.314 0.628
Diabetes mellitus 0.972 0.679-1.384 0.874
Hyperlipidemia 1.212 0.836-1.772 0.314
Osteoarthritis 1.321 0.946-1.845 0.102
Rheumatic arthritis 1.752 0.973-2.934 0.045
Area Capital (R)
Metropolitan 0.790 0.513-1.185 0.268
Rural 0.840 0.577-1.211 0.357
Institution Tertiary (R)
Secondary 0.921 0.596-1.441 0.713
Primary 0.410 0.255-0.666 <0.001
Specialty General practitioner (R)
Neurologist 4.916 2.732-9.186 <0.001
Orthopedist 2.227 1.155-4.346 0.017
Psychiatrist 1.060 0.511-2.198 0.875
Internist 0.228 0.082-0.554 0.002
Others 0.639 0.318-1.280 0.204
c statistic 0.822
P-value of Hosmer-Lemeshow test 0.278

Adj. OR, adjusted odds ratio; CI, confidence interval; NHI, National health insurance; R, reference.

Korean J Clin Pharm 2022;32:313-20 https://doi.org/10.24304/kjcp.2022.32.4.313
© 2022 Korean J Clin Pharm