Korean Journal of Clinical Pharmacy

Table. 2. Table 2

Results of the multiple logistic regression analysis of factors affecting the prescription of contraindicated drug combinations

Explanatory variables		Contraindicated drugs in combinations causing serotonin syndrome

		Adj. OR	95% CI	P-value
Sex	Male (R)
	Female	0.737	0.537-1.015	0.060
Age (years)	20-39 (R)
	40-49	0.691	0.300-1.563	0.374
	50-64	1.791	0.928-3.648	0.093
	65-74	2.120	1.096-4.343	0.031
	≥75	1.313	0.671-2.716	0.442
Insurance	NHI (R)
	Non-NHI	0.716	0.400 -1.191	0.227
Comorbidities	Hypertension	0.915	0.642-1.314	0.628
	Diabetes mellitus	0.972	0.679-1.384	0.874
	Hyperlipidemia	1.212	0.836-1.772	0.314
	Osteoarthritis	1.321	0.946-1.845	0.102
	Rheumatic arthritis	1.752	0.973-2.934	0.045
Area	Capital (R)
	Metropolitan	0.790	0.513-1.185	0.268
	Rural	0.840	0.577-1.211	0.357
Institution	Tertiary (R)
	Secondary	0.921	0.596-1.441	0.713
	Primary	0.410	0.255-0.666	<0.001
Specialty	General practitioner (R)
	Neurologist	4.916	2.732-9.186	<0.001
	Orthopedist	2.227	1.155-4.346	0.017
	Psychiatrist	1.060	0.511-2.198	0.875
	Internist	0.228	0.082-0.554	0.002
	Others	0.639	0.318-1.280	0.204
c statistic		0.822
P-value of Hosmer-Lemeshow test		0.278

Adj. OR, adjusted odds ratio; CI, confidence interval; NHI, National health insurance; R, reference.