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Table. 4.

Table. 4.

Treatment response of vitamin K antagonists (VKAs) according to ABCB1 C3435T polymorphism

Study Note Type of VKAs Response of VKAs

TT type CT type CC type
de Oliveira Almeida VC et al. 2014 Resistance rate n (%) Warfarin 16 (29.6) - -
Ferrari M et al. 2014 TTR >85%
TTR <55%
n (%)
Warfarin 4 (28.6)
10 (71.4)
21 (51.2)
20 (48.8)
8 (72.7)
3 (27.3)
Gschwind L et al. 2015 Hazard ratio for time-to-achieve stability (95% CI) Acenocoumarol 2.81 (1.18-6.67)* 1.12 (0.49-2.55) 1*
Rojo M et al. 2020 TTR (days), n Acenocoumarol 244 [305], 107 240 [299], 135 203 [201], 37
Study Note Type of VKAs Incidence rate of bleeding events

TT type, n (%) CT type, n (%) CC type, n (%)

Yes No Yes No Yes No
Wadelius M et al. 2004 - Warfarin 11 (14.3) 66 (85.7) 21 (18.4) 93 (81.6) 4 (11.8) 30 (88.2)
Sychev DA et al. 2016 - Acenocoumarol 6 (40)* 9 (60) 13 (52)* 12 (48) 1 (10)* 9 (90)

*p<0.05; presented as median [interquartile range] or mean (95% confidence interval CI); VKAs=vitamin K antagonists; TTR=time in therapeutic range

Korean J Clin Pharm 2022;32:238-50 https://doi.org/10.24304/kjcp.2022.32.3.238
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