pISSN 1226-6051
eISSN 2508-786X
eISSN 2508-786X
2×2 contingency table and the related definitions for disproportionality analysis
| 2×2 contingency table for disproportionality calculation | |||
| Target drug | All other drugs | Total | |
| Specific drug | A | B | A+B |
| All other drugs | C | D | C+D |
| Total | A+C | B+D | A+B+C+D |
| Definition and signal detection criteria of implemented data mining indices | |||
| Indices | Definition | Criteria of signal detection | |
| PRR | [A/(A+B)]/[C/(C+D)] | PRR ≥2, Chi-squared ≥4, and A ≥3 | |
| ROR | (A/B)/(C/D) | ROR ≥2, Chi-squared ≥4, and A ≥3 | |
| IC | log[ |
Under limit of 95 % confidence interval ≥0 | |
PRR, proportional reporting ratio; ROR, reporting odds ratio; IC, information component; AE, adverse event