pISSN 1226-6051

eISSN 2508-786X

eISSN 2508-786X

2×2 contingency table and the related definitions for disproportionality analysis

2×2 contingency table for disproportionality calculation | |||

Target drug | All other drugs | Total | |

Specific drug | A | B | A+B |

All other drugs | C | D | C+D |

Total | A+C | B+D | A+B+C+D |

Definition and signal detection criteria of implemented data mining indices | |||

Indices | Definition | Criteria of signal detection | |

PRR | [A/(A+B)]/[C/(C+D)] | PRR ≥2, Chi-squared ≥4, and A ≥3 | |

ROR | (A/B)/(C/D) | ROR ≥2, Chi-squared ≥4, and A ≥3 | |

IC | log[ |
Under limit of 95 % confidence interval ≥0 |

PRR, proportional reporting ratio; ROR, reporting odds ratio; IC, information component; AE, adverse event

Korean J Clin Pharm 2022;32:226-37 https://doi.org/10.24304/kjcp.2022.32.3.226

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