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Table. 4.

Table. 4.

The relationship between the specific type of adverse event and age, sex, and number of concomitant medications

Fluconazole
Gastrointestinal system Psychiatric system Nervous system Fatigue/Fever
aOR p value aOR p value aOR p value aOR p value
Age
< 65 R R R R
≥ 65 1.257 0.125 0.364 <0.001 1.473 0.076 0.652 0.174
Sex
Male R R R R
Female 1.318 0.069 1.587 0.042 0.596 0.015 0.484 0.004
Concomitant medications
0 R R R R
1-3 0.664 0.011 4.215 <0.001 1.764 0.028 0.399 0.001
4-8 0.728 0.091 3.598 <0.001 0.961 0.903 0.262 <0.001
≥ 9 1.143 0.566 7.553 <0.001 0.737 0.497 0.121 0.004
Itraconazole
Gastrointestinal system Psychiatric system Nervous system Fatigue/Fever
aOR p value aOR p value aOR p value aOR p value
Age
< 65 R
≥ 65 1.364 0.225 0.435 0.063 1.154 0.692 0.663 0.305
Sex
Male R R R R
Female 1.146 0.524 0.954 0.867 1.471 0.214 0.629 0.099
Concomitant medications
0 R R R R
1-3 1.361 0.188 1.634 0.136 0.956 0.888 1.1102 0.752
4-8 1.023 0.948 2.308 0.046 0.795 0.642 0.750 0.558
≥ 9 1.114 0.859 0.667 0.704 1.098 0.907 0.483 0.493

aOR, adjusted odds ratio
Korean J Clin Pharm 2022;32:204-14 https://doi.org/10.24304/kjcp.2022.32.3.204
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