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Table. 1.

Table. 1.

Comparison of PBPK, lumping model and 2-compartment model for AUC parameter of voriconazole

Model PBPK model Lumping model 2-Compartment model
Compartment Tissue Tissue AUC0-168h(2-fold range) (hr•mg/L) Tissue AUC0-168hmean (2-fold range) (hr•mg/L) Lumped tissue AUC0-168h (2-fold range) (hr•mg/L) AUC0-168h * (2-fold range) (hr•mg/L)
Central compartment (CEN) Original lungs 38.350 (19.175-76.701) 43.587(21.793-87.174) 46.360(23.180-92.720) 63.400 (31.700-126.802)
Original artery 46.205(23.102-92.410)
Original vein 46.205 (23.103-92.411)
Non-eliminating tissues compartment (NET) Original adipose 447.884 (223.942-895.768) 260.225 (130.112-520.449) 273.008 (136.504-546.016) 63.054 (31.527-126.109)
Original bone 363.089 (181.545-726.179)
Original brain 339.651 (169.826-679.303)
Original muscle 135.747 (67.874-271.494)
Original heart 90.090 (45.045-180.180)
Original rest of body 184.886 (92.443-369.773)

AUC, area under the concentration-time curve; *AUC with plasma profile; Central compartment (CEN), lumped compartment of artery, vein, and lung; Noneliminating tissues compartment (NET), lumped compartment of adipose, bone, brain, muscle, heart, and rest of body

Korean J Clin Pharm 2021;31:125-35 https://doi.org/10.24304/kjcp.2021.31.2.125
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