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Fig. 1.

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Fig. 1. Inter-compatibility among PBPK, lumping model and 2-compartment model Q : blood flow, CL : clearance, lu : lungs, ad : adipose, bo : bone, br : brain, mu : muscle, he : heart, re : rest of body, ki : kidneys, sp : spleen, gu : gut, li : liver, ha : hepatic artery, Central compartment (CEN) : lumped compartment of artery, vein, and lung , Noneliminating tissues compartment (NET) : lumped compartment of adipose, bone, brain, muscle, heart, and rest of body, Ka : absorption rate constant, Vc : central volume of distribution, Vp : peripheral volume of distribution
Korean J Clin Pharm 2021;31:125-35 https://doi.org/10.24304/kjcp.2021.31.2.125
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