pISSN 1226-6051
eISSN 2508-786X
eISSN 2508-786X
The characteristics of included studies
| Author | Study design | Dosing period | Patients | Comment | Jadad score | ||
|---|---|---|---|---|---|---|---|
| N (morning/bedtime) | Dosing time (before morning/after dinner) | Status of hypothyroidism | |||||
| Rajput (2011)8 | RCT | 12 weeks | 152 (77/75) | 0.5 hr/2 hr | Newly diagnosed (dose adjustment of levothyroxine until euthyroid) | No significant difference in drug dosage and duration between the two groups | 3 |
| Bolk (2010)20) | RCT Crossover | 12 weeks | 90 (47/43) | 0.5 hr/- | Stable levothyroxine regimen | Most patients had eaten no food or snacks for several hours before bedtime. | 5 |
| Radhakrishnan (2017)16) | RCT | 12 weeks | 154 (77/77) | 1 hr/2 hr | Patients on a stable levothyroxine regimen | Observe a significant decrease in cholesterol level in the group of patients before bedtime. | 3 |
| Srivastava (2018)21) | RCT Crossover | 6 weeks | 59 (30/29) | 1 hr/2 hr | Patients on a stable levothyroxine regimen | None | 4 |
| Ahmed (2016)18) | RCT | 3 months | 82 (41/41) | 1 hr/2 hr | Newly diagnosed | No significant difference in drug dosage and duration between the two groups | 3 |