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Table. 4.

Table. 4.

Association between dementia and use of cardiovascular medication.

Types of DementiaCVa MedicationCrude OR (95% CI)P-valueAdjusted OR (95% CI)P-value
Alzheimer’s diseaseACEIg or ARBh0.882(0.870, 0.895)<0.0010.791(0.780, 0.803)<0.001
BBi1.096(1.077, 1.115)<0.0010.987(0.970, 1.005)0.154
CCBj1.061(1.045, 1.076)<0.0010.879(0.866, 0.892)<0.001
Diuretics1.519(1.495, 1.543)<0.0011.146(1.128, 1.165)<0.001
Statink0.744(0.733, 0.755)<0.0010.776(0.764, 0.788)<0.001
Vascular dementiaACEIg or ARBh1.111(1.076, 1.147)<0.0011.038(1.006, 1.072)0.021
BBi1.267(1.220, 1.316)<0.0011.173(1.129, 1.218)<0.001
CCBj1.300(1.259, 1.342)<0.0011.144(1.108, 1.182)<0.001
Diuretics1.588(1.532, 1.645)<0.0011.290(1.244, 1.337)<0.001
Statink1.052(1.018, 1.087)0.0021.110(1.074, 1.147)<0.001
Other dementiaACEIg or ARBh0.938(0.902, 0.975)0.0010.870(0.837, 0.904)<0.001
BBi1.333(1.276, 1.394)<0.0011.230(1.176, 1.286)<0.001
CCBj1.203(1.157, 1.250)<0.0011.050(1.010, 1.091)0.014
Diuretics1.744(1.673, 1.818)<0.0011.399(1.342, 1.459)<0.001
Statink0.843(0.810, 0.878)<0.0010.883(0.848, 0.920)<0.001
All dementiaACEIg or ARBh1.109(1.094, 1.123)<0.001.812(0.801, 0.823)<0.001
BBi1.121(1.104, 1.139)<0.0011.014(0.998, 1.031)0.096
CCBj1.087(1.073, 1.102)<0.0010.908(0.896, 0.921)<0.001
Diuretics1.544(1.521, 1.567)<0.0011.177(1.159, 1.195)<0.001
Statink0.773(0.762, 0.784)<0.0010.806(0.795, 0.818)<0.001

g) CV: cardiavascular, g) ACEI: angiotensin converting enzyme inhibitor, h) ARB: angiotensin II receptor antagonists, i) BB: beta-blocking agents, j) CCB: cal-cium channel blockers, k) Statin: HMG CoA reductase inhibitors

Korean J Clin Pharm 2017;27:136-42 https://doi.org/10.24304/kjcp.2017.27.3.136
© 2017 Korean J Clin Pharm