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The Effects after Implementing a Drug Utilization Review System on Contraindicated Drug use: A Systematic Review
Korean J Clin Pharm 2019;29(1):9-17
Published online March 31, 2019
© 2019 Korean College of Clinical Pharmacy.

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Republic of Korea

Heeyoung Lee#, Hyea Suk Choi#, and Eunhee Ji*
Correspondence to: Eunhee Ji, College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Republic of Korea
Tel: +82-32-820-4939, Fax, +82-32-820-4829, E-mail:
#The first two authors contributed equally to this work.
Received November 22, 2018; Revised March 7, 2019; Accepted March 8, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non- Commercial License ( which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.The
Objective: The objective of the present study was to evaluate the effects of implementing a systematic Drug Utilization Review (DUR) system on contraindicated drug use and pharmaceutical expenditures in Korea. Methods: A literature search was conducted using search engines such as PubMed, EMBASE, NDSL, and RISS for relevant systematic studies. The database search was performed and updated in April 2018. Two independent reviewers evaluated the abstracts to find potentially eligible articles. Results: In total, 1433 potentially eligible studies were selected, and 11 articles were eventually shortlisted for inclusion in the present review system. The outcome showed that contraindicated drug use decreased after implementation of the DUR system in Korea. The analysis also showed that the DUR system contributed to a reduction in pharmaceutical expenditures. Conclusions: Our study showed that implementing the DUR system reduced both contraindicated drug use and pharmaceutical expenditures in Korea.
Keywords : Drug utilization review system, contraindicated drugs, pharmaceutical expenditure, systematic review, Korea

March 2019, 29 (1)
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