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Comparison of Sugammadex and Neostigmine on First Spontaneous Breathing and Adverse Effects for Laparoscopic Cholecystectomy
Korean J Clin Pharm 2018;28(2):101-106
Published online June 30, 2018
© 2018 Korean College of Clinical Pharmacy.

HyunSuk Park1,2, Moon Soo Park3, Min Jung Kim2, Kwi Suk Kim2, Yoon Sook Cho2, Seng Sim Bae4, and Sandy Jeong Rhie1,5*

1Graduate School of Converging Clinical and Public Health, Ewha Womans University, Seoul 03760, Republic of Korea
2Department of Pharmacy, Seoul National University Hospital, Seoul 03080, Republic of Korea
3Department of Orthopaedic Surgery Hallym University Sacred Heart Hospital and, Medical College of Hallym University, Anyang-si 14068, Republic of Korea
4Department of Nursing, Seoul National University Hospital, Seoul 03080, Republic of Korea
5College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea
Correspondence to: * Sandy Jeong Rhie, Graduate School of Converging Clinical and Public Health and College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewha Womans University, 52 ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea
Tel: +82-2-3277-3023, Fax: +82-2-3277-2085 E-mail: sandy.rhie@ewha.ac.kr
Received June 6, 2018; Revised June 22, 2018; Accepted June 22, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objective: The purpose of the study was to investigate the time from the injection of muscle relaxants to the first spontaneous respiration between sugammadex and conventional reversal for patients undergoing laparoscopic cholecystectomy.
Methods: This study was retrospectively conducted on patients who were diagnosed with gallbladder stone (N802) between January 2014 and April 2017. The data were collected from the electronic medical records of a total of 186 patients (84 patients in the neostigmine group and 102 patients in the sugammadex group).
Results: The time required for the first spontaneous respiration in the sugammadex group was shorter than that in the neostigmine group (3.6 min vs 4.9 min; p<0.05). After the injection of intermediate muscle relaxants, the comparison of heart rate and mean arterial pressure in the sugammadex and neostigmine groups revealed that the heart rate in the neostigmine group was higher than in the sugammadex group after 5 min (p<0.05). The mean arterial pressure in the neostigmine group was higher than in the sugammadex group after 10 min (p<0.05). A significant adverse effect of tachycardia was observed in the neostigmine group (p<0.05), but the frequency of rescue antiemetic in the sugammadex group was significantly higher than in the neostigmine group (p<0.05).
Conclusion: In this study, the unwanted effect of neostigmine group was tachycardia; therefore, in the case of patients with hemodynamic instability, sugammadex is recommended. At 12 hours after the injection of sugammadex to patients, more antiemetics were required than in the neostigmine group; therefore, more research should be conducted on postoperative nausea and vomiting.
Keywords : Sugammadex, neostigmine, muscle relaxants, laparoscopic cholecystectomy, antiemetic


June 2018, 28 (2)
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