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The Association between Vitamin D Levels and Neonatal Early-onset Sepsis : A Systematic Review and Meta-analysis
Korean J Clin Pharm 2018;28(1):10-16
Published online March 31, 2018
© 2018 Korean College of Clinical Pharmacy.

So Yeon Lee, Ha Eun Kim, and Sook Hee An*

College of Pharmacy, Wonkwang University, Iksan 54538, Republic of Korea
Correspondence to: Sook Hee An, College of pharmacy, Wonkwang University, 460, Iksan-daero, Iksan-si, Jeonbuk 54538, Republic of Korea
Tel: +82-63-850-6821, Fax: +82-63-850-7309
Received March 19, 2018; Revised March 26, 2018; Accepted March 26, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Vitamin D has been associated with sepsis in pediatric and adult patients. The association with neonates is unclear. This systematic review and meta-analysis examined the effect of neonatal and maternal vitamin D levels on neonatal early-onset sepsis.
Methods: We searched studies published up to November 2017 in PubMed/Medline, Embase, and the Cochrane Library databases. All studies that reported 25-hydroxyvitamin D levels in neonates with or without early-onset sepsis were included. Meta-analysis was performed using RevMan 5.3 software.
Results: Four studies were eligible. The weighted mean difference of 25-hydroxyvitamin D levels in neonates with early-onset sepsis and controls was -7.27 ng/mL (95% confidence interval = -7.62, -6.92). Maternal vitamin D levels in neonates with early-onset sepsis were significantly lower than those in controls (weighted mean difference -7.24 ng/mL, 95% confidence interval -8.45, -6.03). All neonates with early onset sepsis had vitamin D deficiency (25-hydroxyvitamin D <20 ng/mL).
Conclusion: Lower neonatal and maternal 25-hydroxyvitamin D levels were associated with neonatal early-onset sepsis. Vitamin D supplementation during pregnancy may be helpful to prevent neonatal early-onset sepsis. The effects of vitamin D supplementation on early-onset sepsis in neonates warrant further study.
Keywords : Neonates, early-onset sepsis, vitamin D

March 2018, 28 (1)
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