pISSN 1226-6051
eISSN 2508-786X
eISSN 2508-786X
Cases of impulse control disorder associated with the use of pramipexole or ropinirole
Case. No. | Reference | Country | Sex/Age | Indication | PRX or ROP dose | PRX/ROP duration | ICD type | ICD treatment | Effectiveness of ICD Treatment | Naranjo Scale Scores |
---|---|---|---|---|---|---|---|---|---|---|
1 | Kolla |
USA | M/61 | Restless leg syndrome | PRX 1 mg/d | Not reported | Hypersexuality; Pathological gambling | Discontinuation | ICD resolved | 6 |
2 | M/65 | Restless leg syndrome | PRX 2 mg/d | Few months | Pathological gambling | Cognitive behavioral therapy | ICD resolved | 4 | ||
3 | Larson |
USA | M/62 | Behavioral variant of frontotemporal dementia | PRX 2.5 mg/d | Not reported | Punding | Discontinuation | ICD resolved | 4 |
4 | Maruno |
Japan | F/62 | Major Depression (Cotard’s Syndrome) | PRX 1 mg/d | 4 months | Disinhibition | Discontinuation | ICD resolved | 4 |
5 | Porta |
Italy | M/31 | PTPSD | PRX 0.033 mg/kg/d | 34 months | Pathological gambling | Discontinuation | ICD resolved | 5 |
6 | M/27 | PTPSD | PRX 0.033 mg/kg/d | 35 months | Compulsive shopping | Switched to levodopa | ICD resolved | 5 | ||
7 | M/16 | PTPSD | PRX 0.032 mg/kg/d | 33 months | Hypersexuality | Dose reduction | ICD resolved | 5 | ||
8 | Quickfall |
Canada | F/52 | Restless leg syndrome | PRX 0.75 mg/d | 2~3 months | Pathological gambling | Dose reduction | ICD resolved | 5 |
9 | Strejilevich |
Argentina | M/56 | Bipolar Disorder | PRX 1.25 mg/d | 44 weeks | Pathological gambling | Switched to bupropion | ICD resolved | 4 |
10 | Tippmann-Peikert |
USA | M/64 | Restless leg syndrome | PRX 0.5 mg/d | 8 months | Pathological gambling | Discontinuation | ICD resolved | 5 |
11 | F/54 | Restless leg syndrome | PRX 0.75 mg/d | 17 months | Pathological gambling | Discontinuation | ICD resolved | 5 | ||
12 | F/56 | Restless leg syndrome | PRX 0.75 mg/d |
17 months | Pathological gambling | Switched to gabapentin | ICD resolved | 7 | ||
13 | F/53 | Restless leg syndrome | PRX 0.7 mg/d |
1 months | Pathological gambling | Discontinuation | ICD resolved | 5 | ||
14 | Cornelinus |
USA | F/60 | Restless leg syndrome | PRX 0.5 mg/d | 1 months | Pathological gambling | Switched to gabapentin | ICD resolved | 5 |
15 | F/47 | Restless leg syndrome | PRX 0.5 mg/d | 6 months | Binge eating; Hypersexuality | Discontinuation | ICD resolved | 5 | ||
16 | M/59 | Restless leg syndrome | ROP 4 mg/d | 12 months | Hypersexuality;, Binge eating; Compulsive shopping | Discontinuation | ICD resolved | 5 | ||
17 | M/79 | Restless leg syndrome | ROP 4 mg/d | 3 months | Compulsive shopping; Binge eating | Not reported | Not reported | 4 | ||
18 | d’Orsi |
Italy | M/71 | Restless leg syndrome | PRX 0.18 mg/d | 5 months | Pathological gambling; Hypersexuality | Switched to gabapentin and clonazepam | ICD resolved | 5 |
19 | Driver-Dunckley et al. (2007)22) | USA | M/77 | Restless leg syndrome | PRX 0.375 mg/d | Not reported | Pathological gambling | Not reported | Not reported | 4 |
20 | M/58 | Restless leg syndrome | PRX 0.125 mg/d | Not reported | Pathological gambling | Not reported | Not reported | 4 | ||
21 | F/58 | Restless leg syndrome | PRX 0.125 mg/d | Not reported | Pathological gambling | Not reported | Not reported | 4 | ||
22 | F/74 | Restless leg syndrome | PRX dose not reported | Not reported | Hypersexuality | Not reported | Not reported | 2 | ||
23 | F/79 | Restless leg syndrome | PRX 2.125 mg/d | Not reported | Hypersexuality | Not reported | Not reported | 4 | ||
24 | F/73 | Restless leg syndrome | ROP dose not reported | Not reported | Pathological gambling; Hypersexuality | Not reported | Not reported | 4 | ||
25 | Holman et al. (2009)33) | USA | F/52 | Fibromyalgia | PRX 4.5 mg/d | 6 months | Pathological gambling | Discontinuation | ICD resolved | 5 |
26 | F/59 | Fibromyalgia | PRX 4.5 mg/d | 12 months | Pathological gambling | Discontinuation | ICD resolved | 5 | ||
27 | F/53 | Fibromyalgia | PRX 4.5 mg/d | 12 months | Pathological gambling; Compulsive shopping | Discontinuation | ICD resolved | 5 | ||
28 | Kim et al. (2008)34) | Korea | M/83 | Supranuclear palsy | PRX 0.25 mg/d | 1 months | Hypersexuality | Switched to levodopa | ICD reappeared 3 weeks later with less intensity | 6 |
29 | Tajima-Pozo et al. (2011)25) | Spain, Italy | M/52 | Restless leg syndrome | PRX 0.7 mg/d | 6 months | Paraphilia | Switched to clonazepam | ICD improved | 5 |
30 | Evans et al. (2009)35) | Australia | F/58 | Restless leg syndrome | ROP 2 mg/d | Immediately | Trichotillomania; Dermatillomania | Discontinuation | Trichotillomania improved only | 4 |
31 | Jones et al. (2011)36) | UK | M/62 | Restless leg syndrome | ROP dose not reported | 2 years | Pathological gambling | Switched to gabapentin and clonazepam | Residual cravings for gambling | 5 |
32 | Fabiani et al. (2015)37) | Brazil | F/40 | Restless leg syndrome | PRX 0.5 mg/d | 3 months | Kleptomania | Dose reduction | ICD reduced | 4 |
33 | Mishima et al. (2015)24) | Japan | F/41 | Perry syndrome | PRX dose not reported | Less than 1 year | Pathological gambling; Compulsive eating | Not reported | Not reported | 3 |
34 | Kalinaga et al. (2019)38) | USA | F/47 | Restless leg syndrome; Depression | PRX 2-3 mg | Less than 1 year | Pathological gambling | Switched to fluoxetine and gabapentin | ICD resolved | 4 |
35 | Hidalgo et al. (2013)39) | Switzerland | F/50 | Restless leg syndrome | PRX 0.18 mg/d | 2 weeks | Hypersexuality | Switched to rotigotin | ICD resolved | 5 |
36 | M/62 | Restless leg syndrome | PRX 0.35 mg/d | 6 weeks | Hypersexuality | Discontinuation | ICD resolved | 6 |
ICD: Impulse control disorder; PRX: Pramipexole; PTPSD: 6-pyruvoyl tetrahydropterin synthase deficiency; ROP: Ropinirole