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Table. 1.

Table. 1.

Cases of impulse control disorder associated with the use of pramipexole or ropinirole

Case. No. Reference Country Sex/Age Indication PRX or ROP dose PRX/ROP duration ICD type ICD treatment Effectiveness of ICD Treatment Naranjo Scale Scores
1 Kolla et al. (2010)21)) USA M/61 Restless leg syndrome PRX 1 mg/d Not reported Hypersexuality; Pathological gambling Discontinuation ICD resolved 6
2 M/65 Restless leg syndrome PRX 2 mg/d Few months Pathological gambling Cognitive behavioral therapy ICD resolved 4
3 Larson et al. (2015)28) USA M/62 Behavioral variant of frontotemporal dementia PRX 2.5 mg/d Not reported Punding Discontinuation ICD resolved 4
4 Maruno et al. (2016)27) Japan F/62 Major Depression (Cotard’s Syndrome) PRX 1 mg/d 4 months Disinhibition Discontinuation ICD resolved 4
5 Porta et al. (2016)29) Italy M/31 PTPSD PRX 0.033 mg/kg/d 34 months Pathological gambling Discontinuation ICD resolved 5
6 M/27 PTPSD PRX 0.033 mg/kg/d 35 months Compulsive shopping Switched to levodopa ICD resolved 5
7 M/16 PTPSD PRX 0.032 mg/kg/d 33 months Hypersexuality Dose reduction ICD resolved 5
8 Quickfall et al. (2017)30) Canada F/52 Restless leg syndrome PRX 0.75 mg/d 2~3 months Pathological gambling Dose reduction ICD resolved 5
9 Strejilevich et al. (2011)26) Argentina M/56 Bipolar Disorder PRX 1.25 mg/d 44 weeks Pathological gambling Switched to bupropion ICD resolved 4
10 Tippmann-Peikert et al.(2007)31) USA M/64 Restless leg syndrome PRX 0.5 mg/d 8 months Pathological gambling Discontinuation ICD resolved 5
11 F/54 Restless leg syndrome PRX 0.75 mg/d 17 months Pathological gambling Discontinuation ICD resolved 5
12 F/56 Restless leg syndrome PRX 0.75 mg/dROP 3.0 mg/d 17 months Pathological gambling Switched to gabapentin ICD resolved 7
13 F/53 Restless leg syndrome PRX 0.7 mg/dROP 0.25 mg/d 1 months Pathological gambling Discontinuation ICD resolved 5
14 Cornelinus et al.(2010)23) USA F/60 Restless leg syndrome PRX 0.5 mg/d 1 months Pathological gambling Switched to gabapentin ICD resolved 5
15 F/47 Restless leg syndrome PRX 0.5 mg/d 6 months Binge eating; Hypersexuality Discontinuation ICD resolved 5
16 M/59 Restless leg syndrome ROP 4 mg/d 12 months Hypersexuality;, Binge eating; Compulsive shopping Discontinuation ICD resolved 5
17 M/79 Restless leg syndrome ROP 4 mg/d 3 months Compulsive shopping; Binge eating Not reported Not reported 4
18 d’Orsi et al. (2011)32) Italy M/71 Restless leg syndrome PRX 0.18 mg/d 5 months Pathological gambling; Hypersexuality Switched to gabapentin and clonazepam ICD resolved 5
19 Driver-Dunckley et al. (2007)22) USA M/77 Restless leg syndrome PRX 0.375 mg/d Not reported Pathological gambling Not reported Not reported 4
20 M/58 Restless leg syndrome PRX 0.125 mg/d Not reported Pathological gambling Not reported Not reported 4
21 F/58 Restless leg syndrome PRX 0.125 mg/d Not reported Pathological gambling Not reported Not reported 4
22 F/74 Restless leg syndrome PRX dose not reported Not reported Hypersexuality Not reported Not reported 2
23 F/79 Restless leg syndrome PRX 2.125 mg/d Not reported Hypersexuality Not reported Not reported 4
24 F/73 Restless leg syndrome ROP dose not reported Not reported Pathological gambling; Hypersexuality Not reported Not reported 4
25 Holman et al. (2009)33) USA F/52 Fibromyalgia PRX 4.5 mg/d 6 months Pathological gambling Discontinuation ICD resolved 5
26 F/59 Fibromyalgia PRX 4.5 mg/d 12 months Pathological gambling Discontinuation ICD resolved 5
27 F/53 Fibromyalgia PRX 4.5 mg/d 12 months Pathological gambling; Compulsive shopping Discontinuation ICD resolved 5
28 Kim et al. (2008)34) Korea M/83 Supranuclear palsy PRX 0.25 mg/d 1 months Hypersexuality Switched to levodopa ICD reappeared 3 weeks later with less intensity 6
29 Tajima-Pozo et al. (2011)25) Spain, Italy M/52 Restless leg syndrome PRX 0.7 mg/d 6 months Paraphilia Switched to clonazepam ICD improved 5
30 Evans et al. (2009)35) Australia F/58 Restless leg syndrome ROP 2 mg/d Immediately Trichotillomania; Dermatillomania Discontinuation Trichotillomania improved only 4
31 Jones et al. (2011)36) UK M/62 Restless leg syndrome ROP dose not reported 2 years Pathological gambling Switched to gabapentin and clonazepam Residual cravings for gambling 5
32 Fabiani et al. (2015)37) Brazil F/40 Restless leg syndrome PRX 0.5 mg/d 3 months Kleptomania Dose reduction ICD reduced 4
33 Mishima et al. (2015)24) Japan F/41 Perry syndrome PRX dose not reported Less than 1 year Pathological gambling; Compulsive eating Not reported Not reported 3
34 Kalinaga et al. (2019)38) USA F/47 Restless leg syndrome; Depression PRX 2-3 mg Less than 1 year Pathological gambling Switched to fluoxetine and gabapentin ICD resolved 4
35 Hidalgo et al. (2013)39) Switzerland F/50 Restless leg syndrome PRX 0.18 mg/d 2 weeks Hypersexuality Switched to rotigotin ICD resolved 5
36 M/62 Restless leg syndrome PRX 0.35 mg/d 6 weeks Hypersexuality Discontinuation ICD resolved 6

ICD: Impulse control disorder; PRX: Pramipexole; PTPSD: 6-pyruvoyl tetrahydropterin synthase deficiency; ROP: Ropinirole

Korean J Clin Pharm 2020;30:250-8 https://doi.org/10.24304/kjcp.2020.30.4.250
© 2020 Korean J Clin Pharm