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eISSN 2508-786X

Table. 3.

Table. 3.

Stratified subgroup analysis evaluating the effect of weight changes on declined cognitive functiona

aOR (95% CI)

SubgroupDecrease >10%Decrease 5% to 10%StableIncrease 5% to 10%Increase >10%
GenderMale1.55 (1.03-2.32)*0.81 (0.55-1.19)Ref1.46 (0.99-2.16)1.70 (1.10-2.64)*
Female1.39 (0.98-1.96)1.12 (0.82-1.53)Ref0.99 (0.68-1.44)1.32 (0.91-1.91)

Age groupAge 45-541.64 (0.83-3.25)0.88 (0.42-1.86)Ref1.35 (0.72-2.52)1.81 (0.92-3.56)
Age 55-641.32 (0.76-2.26)1.11 (0.71-1.71)Ref1.32 (0.82-2.12)1.33 (0.76-2.33)
Age ≥651.45 (1.04-2.03)*0.95 (0.70-1.31)Ref1.08 (0.73-1.58)1.48 (1.01-2.16)*

Baseline BMI groupNormal1.95 (1.22-3.12)***1.29 (0.90-1.86)Ref1.24 (0.85-1.80)1.47 (1.01-2.13)*
Overweight1.43 (0.90-2.27)1.00 (0.65-1.55)Ref1.15 (0.66-2.00)1.47 (0.77-2.81)
Obese1.09 (0.68-1.73)0.64 (0.38-1.06)Ref0.70 (0.34-1.44)1.55 (0.50-4.84)

p<0.05.

**p<0.01.

p<0.001.

Adjusted ORs (95% confidence intervals) were calculated with a multivariate logistic regression model for cognitive decline with all significant

covariates from stepwise selection model presented in Table 2. aOR, adjusted odds ratio; BMI, body mass index; CI, confidence interval; Ref, reference.

Korean J Clin Pharm 2019;29:238-46 https://doi.org/10.24304/kjcp.2019.29.4.238
© 2019 Korean J Clin Pharm