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Table. 3.

Table. 3.

Preference score-based ranking of the 15 research proposals addressing the unmet vaccine safety clinical research needs

RankScore Study populationTarget vaccine(s)Adverse event(s)Data source
144General populationInfluenza vaccineFacial nerve paralysis, Hypersensitivity etc.Linked data between NHIS and KCDC
1 14412-year-old female teenagersHPVAutoimmune diseases, neurological disorders, VTE etc.Linked data between NHIS and KCDC
341General populationInfluenza vaccineNeurological AEs including GBSKAERS and VAERS
433General populationPPSV/PCVAll adverse eventsLinked data between NHIS and KCDC
529Postpartum womenInfluenza and Tdap vaccineN/AData from internet panel survey
625NeonatesBCG vaccineLymphadenitis, osteitis, osteomyelitisLinked data between NHIS and KCDC
724General population born before 1997MMR vaccineN/AData from internet panel survey
814InfantsDTaP vaccineHospitalization, deathLinked data between NHIS and KCDC
913InfantsRotavirus vaccineIntussusceptionLinked data between NHIS and KCDC
1012Rheumatoid arthritis patientsInfluenza vaccineAll adverse eventsLinked data between EMR and vaccination data in KCDC
119General populationVaricella vaccineStroke, encephalitisLinked data between NHIS and KCDC
127Autoimmune disease patientsHPVAll adverse eventsLinked data between EMR and vaccination data n KCDC
127SLE or Rheumatoid arthritis patientsPPSV/PCVAll adverse eventsLinked data between EMR and vaccination data in KCDC
146Women without HPV record prior to pregnancyHPVFetus harm, hospitalization, death etc.Data built direct Registry
155General populationMMR vaccineHSPLinked data between NHIS and KCDC

Additional research topic suggested by the clinical experts

Study populationTarget vaccine(s)Adverse event(s)Primary outcome

Pre-menopausal women visiting the fertility clinicsInfluenza vaccineImplantation failure, chemical pregnancy, miscarriageEffect of influenza vaccine in conceiving
InfantsAll NIP vaccines-The baseline characteristics of vaccinee and non-vaccinee
General populationAll NIP vaccinesAnaphylaxisIncidence of anaphylaxis following NIP vaccines
Patients with chronic illness excluding immunosuppressionLive attenuated herpes zoster vaccineVaricella or ash caused by herpes zosterSafety profile of herpes zoster vaccine

KAERS, Korea Adverse Event Reporting System; VAERS, Vaccine Adverse Event Reporting System; PCV, pneumococcal conjugate vaccine; PPSV, pneumococcal polysaccharide vaccine; Tdap, Tetanus, reduced diphtheria and acellular pertussis; BCG, Bacillus Calmette-Guérin; MMR, Measles, Mumps, and Rubella; DTaP, Diphtheria, Tetanus and acellular Pertussis; HPV, human papillomavirus; NIP, national immunization program; GBS, Guillain-Barre syndrome; AE, Adverse Event; KCDC, Korea Centers for Disease Control and Prevention; SLE, Systemic Lupus Erythematosus; HSP, Henoch-schönlein Purpura

Korean J Clin Pharm 2019;29:173-85 https://doi.org/10.24304/kjcp.2019.29.3.173
© 2019 Korean J Clin Pharm