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Table. 1.

Table. 1.

Demographic characteristics of study population

CaseControlp-value

(n=14,295)(n=63,435)

n%n%
Age*50~593,32123.214,15922.3Matched
60~693,76126.316,62626.2
70~794,62632.420,96233.0
80~2,58718.111,68818.4

Gender*Male3,52624.715,29724.1Matched
Female10,76975.348,13875.9

Health insurance type*NHI for non-employee5,34837.423,03836.3<0.001
NHI for employee7,52952.735,51756.0
Medical aid1,4189.94,8807.7

Income level*1st quintile3,64025.513,86121.9<0.001
2nd quintile2,81219.712,53519.8
3rd quintile2,80419.612,48019.7
4th quintile1,98513.99,41814.8
5th quintile3,05421.415,14123.9

CCI"Mean (SD)3.433 (2.605)3.384 (2.549)Matched
01,3389.45,9149.3
1-24,73833.121,29633.6
3-44,17129.218,58629.3
≥54,04828.317,63927.8

Comorbidity**Osteoporosis3,54024.816,29825.7Matched
Diabetes mellitus3,58525.118,41829.0<0.001
Rheumatoid arthritis1,1388.04,1726.6<0.001
Parkinson’s disease2872.091 41.4<0.001
COPD9706.83,8396.10.001
Hypercalciuria1 971.46191.0<0.001
Idiopathic scoliosis1611.15360.80.001

Medication***Aluminum3002.11,0451.6<0.001
Glucocorticoids1681.23300.5<0.001
SSRI5063.51,6132.5<0.001
Estrogens2051.41,1631.80.001
Raloxifen440.31 440.20.076
Bisphosphonate**2,57718.06,96111.0<0.001

In the year of 2001

within 2 years before the index date

within 6 months before the index date

NHI, national health insurance; CCI, Charlson’s comorbidity index; SD, standard deviation; COPD, chronic obstructive pulmonary disease; SSRI, selective serotonin reuptake inhibitors

Korean J Clin Pharm 2019;29:147-55 https://doi.org/10.24304/kjcp.2019.29.3.147
© 2019 Korean J Clin Pharm