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Table. 3.

Table. 3.

Association of vertebral fracture and proton pump inhibitor use

Case (n=7,586)Control (n=26,963)Crude* Odds ratio(95% CI)Adjusted** Odds ratio(95% CI)

n%n%
Unexposed542271.520,32875.4ReferenceReference
Exposed2,16428.5663524.61.19(1.12,.26)1.13(1.07,.21)
Timing of the last exposure
 Current2943.97702.91.39(1.21,.60)1.30(1.13,.50)
 Most recent5567.314515.41.39(1.25,.54)1.30,(1.17,.45)
 Recent3144.19713.61.16(1.02,.33)1.12,(0.98, 1.28)
 Recent past4526.015115.61.10(0.99, 1.23)1.06(0.94, 1.18)
 Past5487.219327.21.05(0.95, 1.17)1.01(0.91,.12)
p for trend0.00240.0847

Number of prescription days
 <301,01613.43,30712.31.13(1.05,.22)1.09(1.00,.18)
 30≤, <906098.01,8747.01.19(1.08,.31)1.13(1.02,.25)
 90≤, <3654215.51,1644.31.30(1.15,.46)1.23(1.09,.39)
 365≤1181.62901.11.47(1.18,.83)1.36(1.09,.70)
p for trend<0.0001<0.0001

Cumulative dose
 0< DDD <301,11714.73,59013.31.15(1.06,.24)1.10(1.02,.19)
 30≤ DDD <905927.81,7876.61.21(1.09,.34)1.15(1.04,.27)
 90≤ DDD <1802313.07112.61.16(0.99, 1.35)1.11(0.95, 1.29)
 180≤ DDD <3651672.23901.41.56(1.30,.88)1.48(1.23,.80)
 365≤ DDD570.81570.61.29(0.94, 1.75)1.15(0.84, 1.57)
p for trend<0.0001<0.0001

Calculated by conditional logistic regression

Calculated by conditional logistic regression adjusted for diabetes mellitus, rheumatoid arthritis, Parkinson’s disease, chronic obstructive pulmonary disease, hypercalciuria, idiopathic scoliosis, aluminum, glucocorticoids, selective serotonin reuptake inhibitors, estrogens, raloxifen, bis- phosphonate ***Current: currently taking PPI at the index date; most recent: 1~90 days before the index date; recent: 91~180 days before the index date; recent past: 181~365days before the index date; past: more than 365 days before the index date DDD, defined daily dose

Korean J Clin Pharm 2019;29:147-55 https://doi.org/10.24304/kjcp.2019.29.3.147
© 2019 Korean J Clin Pharm