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Table. 2.

Table. 2.

Association of major fracture (vertebral, arm and hip) and proton pump inhibitor use

Case (n= 14,295)Control (n=63,435)Crude* Odds ratio (95% CI)Adjusted** Odds ratio (95% CI)

n%n%
Unexposed10,52373.648,19276.0ReferenceReference
Exposed3,77226.415,24324.01.11(1.06,.16)1.06(1.01,.11)

Timing of the last exposure***
 Current4533.21,7122.71.19(1.06,.32)1.11(1.00,.25)
 Most recent8896.23,2805.21.21(1.12,.31)1.14(1.05,.24)
 Recent5333.72,2263.51.07(0.97, 1.18)1.02(0.92, 1.13)
 Recent past8485.93,5365.61.08(1.00,.17)1.03(0.95, 1.12)
 Past1,0497.34,4897.11.05(0.98, 1.13)1.01(0.94, 1.09)
p for trend0.00390.2475

Number of prescription days
 <301,84412.97,75112.21.08(1.02,.14)1.03(0.98, 1.10)
 30≤, <901,0847.64,3306.81.12(1.04,.21)1.06(0.99, 1.15)
 90≤, <3656624.62,5464.01.15(1.04,.26)1.08(0.98, 1.19)
 365≤1821.36161.01.30(1.09,.55)1.20(1.00,.43)
p for trend<0.00010.0044

Cumulative dose
 0< DDD <302,00314.08,33313.11.08(1.02,.14)1.04(0.98, 1.10)
 30≤ DDD <901,0607.44,1986.61.14(1.05,.22)1.08(1.00,.16)
 90≤ DDD <1803742.61,5412.41.05(0.93, 1.19)0.99(0.88, 1.12)
 180≤ DDD <3652431.78641.41.27(1.09,.48)1.21(1.04,.41)
 365≤ DDD920.63060.51.32(1.03,.68)1.18(0.92, 1.51)
p for trend<0.00010.0059

Calculated by conditional logistic regression

Calculated by conditional logistic regression adjusted for diabetes mellitus, rheumatoid arthritis, Parkinson’s disease, chronic obstructive pulmonary disease, hypercalciuria, idiopathic scoliosis, aluminum, glucocorticoids, selective serotonin reuptake inhibitors, estrogens, raloxifen, bis- phosphonate

Current: currently taking PPI at the index date; most recent: 1~90 days before the index date; recent: 91~180 days before the index date; recent past: 181~365days before the index date; past: more than 365 days before the index date DDD, defined daily dose

Korean J Clin Pharm 2019;29:147-55 https://doi.org/10.24304/kjcp.2019.29.3.147
© 2019 Korean J Clin Pharm